Chemically-synthesized SF-silica fusion proteins. A, Silk hydrogelation mechanism. B, Biomineralization of biosilica particles catalyzed by the biosilica selective peptide R5. C, Design strategy and processing to create silica micropatterns. D-F, SEM (D and E) and visual (F) images show mineralized peptide logo with microscale patterns (1.2 cm width). G, Fluorescence images of FITC-labeled R5 patterns on the silk hydrogels. Reproduced with permission.[102] Copyright 2018, John Wiley and Sons.