Figure 8.

Potassium gluconate reduces myofibroblast population and increases blood vessel density. Cryosections of the wound sites were immunostained against αSMA. (A-C) Representative images of wound sites treated with (A) vehicle (control), (B) KG-Low, and (C) KG-High. Dotted lines indicate the dermal-epidermal junction. Arrowheads indicate representative blood vessels. Scale: 500 μm. Quantification of (D) αSMA positive area in the wound site normalized to DAPI. (E) Quantification of the blood vessel density within wound sites. * (p<0.05), ** (p<0.01), and brackets indicates significance between indicated conditions as determined by one-way ANOVA with Holm-Sidak post hoc analysis (n=3).