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Effects of donepezil, memantine, melatonin, and LW on anxiety behavior in old SAMR1 mice. (A) Time spent in the open quadrants, (B) number of the open quadrants entries, and (C) total distance traveled in the elevated zero maze test. *P < 0.05, **P < 0.01 vs control group. Kruskal-Wallis test, mean ± S.D., n=11~13(male: n = 4~5, female: n = 7~8).
