Fig 3. Time courses (a: BOLD; b: b1000; c: b1800; d: ADC)—Time courses of signal in V1 with saline (upper row) and TGN-020 (lower row).

(a) BOLD, (b) DfMRI (b = 1000 [s/mm²]), (c) DfMRI (b = 1800 [s/mm²]), (d) DfMRI (ADC). The amplitude of the BOLD response after TGN-020 administration (red line) is significantly larger than the pre-administration response (blue line), while the amplitude of the DfMRI and ADC responses after TGN-020 administration are not significantly different. The color bands represent the standard deviation (SD) between subjects (n = 9). The visual stimulus was applied between 10 and 30 seconds (gray bar). An asterisk indicates a significant difference between pre-administration and post-administration (paired t-test, p<0.05). Note that the onset and offset of the DfMRI signal response occur earlier than for the BOLD fMRI responses.