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. 2020 May 11;16(5):e1008576. doi: 10.1371/journal.ppat.1008576

Fig 8. YopH dephosphorylates SKAP2-dependent and independent signaling proteins inhibiting ROS production and degranulation in neutrophils.

Fig 8

(A) After integrin engagement, YopH inhibits signal propagation that is required for the activation of the NADPH oxidase complex and degranulation while SKAP2 is essential for ROS and phagocytosis and for maximal ERK1/2 phosphorylation, but not for degranulation or phosphorylation of Syk, SLP-76 and PLCγ2. (B) After GPCR stimulation of LPS-primed neutrophils with fMLP, YopH inhibits ROS and degranulation, where SKAP2 is required for ROS production, but not degranulation. (C) YopH inhibits ROS and degranulation after FcγR stimulation and reduces phosphorylation of Syk, SLP-76, PLCγ2 and ERK1/2, but SKAP2 is not required for ROS production, degranulation, nor phosphorylation of these signaling proteins.