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. 2020 May 11;16(5):e1008577. doi: 10.1371/journal.ppat.1008577

Fig 4. Q563R reduces Env infectivity by disrupting membrane fusion and six-helix bundle formation.

Fig 4

(A) Relative infectability of TZM-bl cells by viruses with NE1, E1, NE1 Q563R and E1 R563Q Envs, normalized for RT activity. (B) Relative fusion of TZM-bl cells with NE1, E1, NE1 Q563R and E1 R563Q Blam-Vpr viruses, normalized to Env NE1 virus levels. Inhibition of infection of TZM-bl cells by viruses with these Envs in the presence of the (C) C34 peptide and (D) D5 monoclonal antibody. All assays were done in triplicate. Data are represented as mean values; error bars indicate SEM. The dotted line indicates 50% infection.