Fig 6. Viruses with Q563R Envs exhibit increased sensitivity to neutralization by MPER bNAbs.

Infection of TZM-bl cells by NE1, NE1 Q563R, E1 and E1 R563Q viruses was tested in the presence of MPER-targeted bNAbs (A) 10E8, (B) 7H6, (C) 2F5, (D) Z13e1 and (E) 4E10, with (F) IC50 values as indicated. All assays were conducted in triplicate. Data are represented as mean values; error bars indicate SEM. The dotted line indicates 50% infection.