Table 3.
Right common carotid artery mechanical properties and aortic stiffness in the 4 groups of subjects
| Parameters | NTN | HTN | MetS | CKD |
|---|---|---|---|---|
| Number of subjects | 15 | 16 | 15 | 16 |
| Right common carotid artery | ||||
| Systolic BP (mm Hg) | 102 ± 14 | 122 ± 16** | 133 ± 18** | 121 ± 16** |
| Diastolic BP (mm Hg) | 69 ± 8 | 77 ± 9* | 78 ± 8* | 76 ± 8* |
| Mean BP (mm Hg) | 83 ± 10 | 96 ± 11** | 99 ± 10** | 94 ± 9* |
| Pulse pressure (mm Hg) | 33 ± 9 | 45 ± 12* | 55 ± 17** | 45 ± 14** |
| Internal diameter (mm) | 5.36 ± 0.59 | 5.55 ± 0.75 | 5.86 ± 1.29 | 5.94 ± 0.78 |
| IMT (µm) | 876 ± 132 | 861 ± 149 | 831 ± 142 | 928 ± 121 |
| Wall/lumen | 0.17 ± 0.03 | 0.16 ± 0.04 | 0.15 ±0.04 | 0.16 ± 0.03 |
| WCSA (mm2) | 17.2 ± 3.5 | 17.3 ± 3.2 | 17.6 ± 4.9 | 20.1 ± 4.5 |
| Circumferential wall stress (kPa) | 33.9 ± 4.8 | 41.7 ± 11.9 | 46.8 ± 16.3* | 40.4 ± 9.6 |
| Young elastic modulus (kPa) | 217 ± 477 | 477 ± 347** | 1,009 ± 832** | 448 ± 260** |
| Distensibility (kPa−1 × 10−3) | 37.1 ± 13.0 | 19.4 ± 7.5* | 13.3 ± 8.7** | 20.2 ± 8.8* |
| Stiffness (m/s) | 5.5 ± 1.1 | 7.7 ± 1.9** | 10.6 ± 4.4** ,† | 7.6 ± 2.0** ,‡ |
| Aortic stiffness | ||||
| Carotid femoral PWV (m/s) | 7.8 ± 1.3 | 9.4 ± 1.3* | 10.4 ± 2.7* | 9.7 ± 2.2* |
Large vessel study was performed in normotensive subjects (NTN), and patients with hypertension (HTN) associated or not with other features of the metabolic syndrome (MetS) or with chronic kidney disease (CKD) at visit 2. Data are shown as means ± SD. Comparisons between multiple groups were analyzed by one-way analysis of variance (ANOVA) followed by a Student–Newman–Keuls post hoc test or in absence of normal distribution, a Kruskal–Wallis one-way ANOVA followed by a Dunn’s multiple comparison test, as appropriate. *P < 0.05 and **P < 0.001 vs. NTN, †P < 0.05 vs. HTN, ‡P < 0.05 vs. MetS. Abbreviations: BP, blood pressure; IMT, intima media thickness; PWV, pulse wave velocity; WCSA, wall cross-sectional area.