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. 2020 May;143(5):1555–1571. doi: 10.1093/brain/awaa097

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© The Author(s) (2020). Published by Oxford University Press on behalf of the Guarantors of Brain.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Principal component analysis scores of clinical features in FTLD syndromes. Six principal components (A–F) were selected. (A) Syndrome dimension 1: clinician and carer ratings of behavioural impairment. (B) Syndrome dimension 2: global cognitive impairment, composed of all ACE-R subscores. (C) Syndrome dimension 3: supranuclear gaze palsy, postural stability and symmetrical rigidity (positive loading) and semantic language impairment (negative loading). (D) Syndrome dimension 4: asymmetrical parkinsonism, dystonia, myoclonus with limb apraxia, cortical sensory loss and alien limb syndrome. (E) Syndrome dimension 5: agrammatic, apraxic and logopenic language impairments. (F) Syndrome dimension 6: carer ratings of low mood and abnormal beliefs.