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. 2020 May;143(5):1555–1571. doi: 10.1093/brain/awaa097

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© The Author(s) (2020). Published by Oxford University Press on behalf of the Guarantors of Brain.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Source-based morphometry (based on independent component analysis) of combined grey and white matter. A subset of components is shown (all components are provided in the Supplementary material). Fifteen components were selected, each representing a region of independently covarying grey and white matter atrophy. Images are standardized group spatial maps for each component, superimposed on an average of all brain images. The scatter-box plots show the standardized subject loading coefficients, grouped by FTLD syndrome subtype.