Figure 6.

Structure-phenotype associations using canonical correlation analysis with phenotypic (syndrome dimensions from PCA) and structural (atrophy components from source-based morphometry) information. Three canonical correlation components were selected, each composed of multiple imaging and clinical phenotype components. (A) First canonical correlation. Atrophy in the motor cortex and brainstem had the greatest loading onto the imaging component. Syndrome dimensions 3 (PSP-like motor features) and 4 (CBS-like motor features) had positive loadings and syndrome dimension 2 (global cognitive impairment) had negative loading on the clinical component. (B) Second canonical correlation. Atrophy in the frontal and temporal lobes had the greatest loading on the imaging component. On the clinical component, syndrome dimension one (behavioural impairment) had positive loadings. (C) Third canonical correlation. A spread of cortical and subcortical atrophy components loaded on the imaging component and syndrome dimensions 1–3 contributed to the clinical component. Plots of loadings onto all imaging and clinical components are provided in the Supplementary material.