Table 1:
Baseline Patient Characteristics and Outcomes of the Study Population
| Variable | Cohort (n=321) |
|---|---|
| Age | 60 (52,69) |
| Female n (%) | 179 (55.8) |
| African-American n (%) | 155 (48.7) |
| Hispanic n (%) | 2 (0.6) |
| Education (years) | 12 (10, 12) |
| APACHEa II | 21 (15, 26) |
| Charlson Comorbidity Index | 3 (1, 5) |
| Activities of Daily Living (ADL) | 6 (5, 6) |
| Instrumental Activities of Daily Living (IADL) | 8 (3,8) |
| IQCODEb | 3 (3, 3.3) |
| Mechanically Ventilated n (%) | 196 (61.1) |
| ICU Location | |
| Medical ICU n (%) | 219 (68.2) |
| Surgical ICU n (%) | 76 (23.7) |
| Progressive/step-down ICU n (%) | 26 (8.1) |
| Diagnoses n (%) | |
| Acute Respiratory Failure and/or Sepsis | 167 (52) |
| Neurological conditionsc | 26 (8) |
| Othersd | 128 (40) |
| Biomarker values | |
| S-100β ng/ml | 0.11 (0.06, 0.21) |
| IL-6e pg/ml | 22.0 (7.0, 49.9) |
| IL-8 pg/ml | 27.1 (15.0, 58.8) |
| IL-10 pg/ml | 8.9 (2.5, 22.7) |
| IGF-1f ng/ml | 36.4 (26.1, 62.5) |
| C-Reactive Protein μg/ml | 30.9 (19.3, 40.6) |
| TNF-alphag pg/ml | 10.7 (5.8, 17.9) |
| Outcomes | |
| Delirium duration in days | 2 (0, 4) |
| Delirium/coma free days by one week | 5 (2, 7) |
| Delirium/coma free days by 30 days | 26 (19, 29) |
| Delirium severity by one week mean (SD) | 3.8 (1.6, 5.8) |
| Delirium severity by discharge mean (SD) | 2.8 (1.3, 4.6) |
| ICU length of stay (days) | 10 (5, 17) |
| Hospital length of stay (days) | 12 (8, 21) |
| ICU mortality n (%) | 30 (9.4) |
| In-hospital mortality n (%) | 35 (10.9) |
a
Acute Physiology and Chronic Health Evaluation Score
b
Informant Questionnaire on Cognitive Decline in the Elderly
c
Neurological conditions include traumatic brain injury, status epilepticus and cerebrovascular accidents
d
Others: Include trauma, cardiovascular and gastrointestinal diagnoses
Values are presented as median (interquartile ranges) unless otherwise specified
e
IL: Interleukin
f
IGF-1: Insulin-like growth factor-1
g
TNF: Tumor Necrosis Factor