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. 2019 Oct 26;14(4):525–537. doi: 10.1093/ecco-jcc/jjz175

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© European Crohn’s and Colitis Organisation 2019.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — Immunopathology of quiescent IBD reflects B cell dysregulation. A: Proportions of Tfh-like [CXCR5⁺] CD4/CD8 T cells and gut-homing [integrin-β7⁺] T cells in PBMC of healthy control and IBD donors. B: Circulating plasmablasts [CD38^hi CD27⁺ CD19⁺] and B cell subsets in healthy and IBD donors. Kruskal-Wallis tests were used to compare groups [n = 23 HC; n = 18 CD; n = 17 UC]. C: IgA coating of IEM obtained from right colon biopsies of example HC, CD, and UC donors, after gating on SYBR Green⁺ events. D: Pooled data showing proportions of IgA⁺ IEM in donor groups. One-way ANOVA was used to compare groups [n = 25 HC; n = 9 CD; n = 19 UC]. IBD, inflammatory bowel disease; PBMC, peripheral blood mononuclear cells; HC, healthy controls; CD, Crohn’s disease; UC, ulcerative colitis; IEM, intraepithelial microbes.