Table 1. Proteins reported to be involved in neurodegenerative diseases.

Phenotype/Disease	Gene product/Role in mitochondrial function	Induced dysfunction	References
PD	Pink1/Mitochondrial morhogenesis, mitophagy, mitochondrial fission-fusion, mitochondria transport in axon	Neurons degeneration accompanied with mitochondria- related structural alterations	[73]–[75]
PD	Parkin/Mitochondrial biogenesis, UPS, mitophagy, antioxidant defense	Impaired mitochondrial function and morphology, oxidative damage	[73],[76],[77]
PD	Alpha-synuclein/Mitophagy, ROS formation, mitochondrial fusion	Mitochondrial fragmentation, impaired respiratory complex	[78],[79]
PD	LRRK2/Regulating mitochondrial homeostasis	Reduced mitochondrial membrane potential and total intracellular ATP levels, mitochondrial elongation and interconnectivity	[80],[81]
CMT2A	Mfn2/fusion, transportation of mitochondria, axonal transport	Accumulations in mitochondrial network, Aberration in Δψm, Disorders in mitochondrial fusion	[38],[71],[82],[83]
CMT4A	GDAP1/fission, regulation of mitochondria network	Elongated mitochondria, Oxidative stress, Neuronal demyelization	[36],[84],[85]
Abnormal brain development, Optic atrophy	Drp1/fission	Elongated mitochondria, fission disruption	[29],[30],[39],[86]
Dominant Optical Atrophy	OPA1/fusion	Fragmented mitochondria, Aberrations in ATP production, Δψm and oxygen consumption, Instability of mtDNA, Sensitivity to apoptosis	[24],[27],[28],[64],[66],[87]