Fig. 3.

The effects of baclofen on dorsolateral prefrontal cortex (dlPFC) in the Brain at Rest Predict responses to smoking cues (SCs). (A) Coronal, axial, sagittal, and 3D images showing a baclofen-induced increase in right dlPFC cerebral blood flow (CBF) in the brain at rest, Z = 2.95, p = 0.021. (B) The dlPFC increase in the brain at rest predicted a decrease in the neural response to SCs in the ventral medial prefrontal cortex, Z = 4.33, p _FWEcorr = 0.002 (top 3D image) and the left ventral anterior insula, Z = 3.85, p _FWEcorr = 0.002 (bottom 3D image). Coordinates are in MNI space. Clusters are defined via whole-brain voxel-wise analysis. Values are family-wise error (FWE) corrected.