Table 2.
Baclofen titration schedule
| Study day | 8:00 AM | 12:00 PM | 4:00 PM | 8:00 PM |
|---|---|---|---|---|
| Day 1 | PBO | 10 BAC | PBO | 10 BAC |
| Day 2 | PBO | 10 BAC | 10 BAC | 10 BAC |
| Day 3 | PBO | 20 BAC | 20 BAC | 20 BAC |
| Day 4−7 | 20 BAC | 20 BAC | 20 BAC | 20 BAC |
| Week 2−7 | 20 BAC | 20 BAC | 20 BAC | 20 BAC |
| Week 8 Day 1−2 | PBO | 20 BAC | 20 BAC | 20 BAC |
| Week 8 Day 3−4 | PBO | 20 BAC | PBO | 20 BAC |
| Week 8 Day 5−6 | PBO | 10 BAC | PBO | 10 BAC |
| Week 8 Day 7 | PBO | PBO | PBO | PBO |
Baclofen (BAC) was titrated up to full dose (week 1) and tapered down (week 8) to mitigate adverse effects, including drowsiness. Placebo medication (PBO) was used to ensure blinding during the titration process.