Table 3.
Summary of the significant results from analyses
| SNP | Variable | Type of analysis | Raw pvalue | Analysis details | ||
|---|---|---|---|---|---|---|
|
| ||||||
| Mean | Statistic value | 95% CI | ||||
| Cross-diagnosis merged sample (MDD + AD + BPD - Kor + Ita) | ||||||
| rs1344706 | Psychosis | Genotypic | 4.154E-04 | GG vs. TT | B = 1.398, SE = 0.409, p = 0.001, OR = 4.045 | 1.814−9.020 |
| TG vs. TT | B = 1.165, SE = 0.366, p = 0.001, OR = 3.207 | 1.566−6.570 | ||||
| Allelic | 1.063E-04 | not G vs. G | B = −1.239, SE = 0.351, p = 0.000, OR = 0.290 | 0.145−0.577 | ||
| Cross-diagnosis Italian sample (MDD + AD + BPD - Ita) | ||||||
| rs7597593 | Symptom improvement (HDRS) | Allelic | 5.299E-04 | C: m = 13.364 | Err. = 0.484 | 12.406−14.322 |
| not C: m = 13.463 | Err. = 0.927 | 11.629−15.297 | ||||
| Bipolar merged sample (BPD - Kor + Ita) | ||||||
| rs1344706 | Disease | Genotypic | 5.769E-06 | GG vs. TT | B = −1.054, SE = 0.219, p = 0.000, OR = 0.349 | 0.227−0.535 |
| TG vs. TT | B = −0.564, SE = 0.186, p = 0.002, OR = 0.569 | 0.396−0.819 | ||||
| Allelic | 2.783E-05 | not G vs. G | B = 0.727, SE = 0.175, p = 0.000, OR = 2.069 | 1.469−2.913 | ||
| Psychosis | Allelic | 2.009E-03 | not G vs. G | B = −1.197, SE = 0.413, p = 0.004, OR = 0.302 | 0.134−0.679 | |
| Antimanic response | Genotypic | 1.215E-03 | GG vs. TT | B = 1.862, SE = 0.599, p = 0.002, OR = 6.435 | 1.990−20.815 | |
| TG vs. TT | B = 1.072, SE = 0.395, p = 0.007, OR = 2.920 | 1.346−6.334 | ||||
| Allelic | 7.377E-04 | not G vs. G | B = −1.278, SE = 0.375, p = 0.001, OR = 0.279 | 0.134−0.581 | ||
| rs1344706 | HDRS score at baseline | Genotypic | 7.872E-04 | GG: m = 9.750 | Err. = 0.897 | 7.985−11.515 |
| TG: m = 11.836 | Err. = 0.567 | 10.719−12.952 | ||||
| TT: m = 13.931 | Err. = 0.665 | 12.623−15.240 | ||||
| Allelic | 1.210E-03 | G: m = 11.240 | Err. = 0.482 | 10.292−12.188 | ||
| not G: m = 13.931 | Err. = 0.668 | 12.617−15.246 | ||||
| YMRS score at baseline | Genotypic | 2.159E-07 | GG: m = 26.811 | Err. = 2.148 | 22.582−31.041 | |
| TG: m = 19.992 | Err. = 1.393 | 17.249−22.735 | ||||
| TT: m = 11.571 | Err. = 1.706 | 8.212−14.931 | ||||
| Allelic | 1.102E-06 | G: m = 22.011 | Err. = 1.182 | 19.683−24.339 | ||
| not G: m = 11.571 | Err. = 1.726 | 8.173−14.970 | ||||
| Symptom improvement (YMRS) | Genotypic | 3.153E-07 | GG: m = 17.363 | Err. = 1.290 | 14.822−19.904 | |
| TG: m = 12.738 | Err. = 0.821 | 11.122−14.355 | ||||
| TT: m = 8.259 | Err. = 1.024 | 6.243−10.275 | ||||
| Allelic | 2.537E-06 | G: m = 14.071 | Err. = 0.703 | 12.685−15.456 | ||
| not G: m = 8.259 | Err. = 1.040 | 6.211−10.307 | ||||
| Depressed bipolar Italian sample (BPD.D - Ita) | ||||||
| rs7597593 | Symptom improvement (HDRS) | Allelic | 1.636E-03 | C: m = 14.799 | Err. = 0.437 | 13.931−15.666 |
| not C: m = 14.674 | Err. = 0.826 | 13.036−16.312 | ||||
SNP, single nucleotide polymorphism; 95% CI, 95% confidential interval; MDD, major depressive disorder; AD, depressed subsample of anxiety disorder; BPD, bipolar disorder; BPD.D, depressed subsample of BPD; Kor, Korean; Ita, Italian; SE, standard error; OR, odds ratio; HDRS, Hamilton Depression Rating Scale; YMRS, Young Mania Rating Scale.