Fig. 4.

Effects of different doses of Citicoline (100, 250, 500 mg/kg) on the latency time in Passive Avoidance test. The latency index values have been shown for the studied group. The data represent as means ± standard error of mean of 7 mice per group. AlCl3 was orally administrated for 28 days. Citicoline was injected intraperitoneally for 28 consecutive days. RVT, rivastigmine injected intraperitoneally for 28 days at the dose of 2 mg/kg; AlCl3, Aluminium chloride.

***p < 0.001 vs. AlCl3-treated group. ^# p < 0.001 vs. control vehicle treated group (Tukey test).