Table 3.

Multivariable Logistic Regression Analysis of Independent Factors Related to Marijuana Use in Patients with Symptoms of Gastroparesis (N=477)^{* †}

	Marijuana Use
Clinical Factors	Odds ratioǂ	95% Confidence Interval	P‡
Smoking: Former smoker vs. non-smoker	4.90	2.15 – 11.18	<0.001
Current smoker vs. non-smoker	14.24	5.91 – 34.28	<0.001
Age at enrollment (/years)	0.94	0.91 – 0.97	<0.001
PAGI-SYM: Upper abdominal pain sub-score (/score)	1.35	1.05 – 1.75	0.02
Non-married vs. married	2.41	1.17 – 5.00	0.02
Etiology: Diabetic vs. Idiopathic gastroparesis	2.25	1.04 – 4.87	0.04
Non-Latino/Hispanic vs. Latino or Hispanic	3.41	1.07 – 10.83	0.04
Use of alternative medicine (yes vs. no)	2.00	1.00 – 3.99	0.05
Initial infectious prodrome (yes vs. no)	1.76	0.84 – 3.68	0.14
Alcohol use (yes vs. no)	1.73	0.87 – 3.43	0.08

^*Model variables selected from a candidate set of 37 baseline variables using Akaike Information criteria (AIC) with backward selection using logistic regression. The candidate set of baseline variables included: gastric emptying (normal vs. delayed), etiology of gastroparesis (idiopathic vs. diabetic), gender (female vs. male), ethnicity (Hispanic vs. non-Hispanic), race (white vs. non-white), age, BMI, smoking status (non-smoker/ former smoker/ current smoker), alcohol use (yes vs. no), Rome III identified cyclic vomiting syndrome (yes vs. no), married vs. non-married, acute symptom onset vs. insidious onset, college (yes vs. no), income above $50,000 (yes vs. no), infectious prodrome (yes vs. no), hospitalizations in past year (yes vs. no), nature of gastroparesis symptoms, severity of gastroparesis (mild/ compensated/ severe), use of alternative medicine (yes vs. no), psychiatric diagnoses (anxiety, bipolar, eating disorders, major depression, obsessive compulsive disorder, personality disorder), STAI state score, STAI trait score, Beck Depression Inventory score, PAGI-SYM sub-scores, PAGI-QOL sub-scores, SF36 Physical and Mental components, Somatic Symptom category, and PHQ-15 score.

^†Post-Nissen gastroparesis subjects (N=24) excluded due to low number. 5 additional subjects excluded due to one or more missing variables.

^ǂOdds of marijuana use vs. no marijuana use. Prevalence of marijuana use: N=59 (12.4%)

^‡P-values determined from multiple regression (2-sided). Bolded p’s denote <0.05.