Table:
Patient Characteristics
| Baseline Characteristics on Admission | N, Mean or Median |
|---|---|
| Number of critically ill patients | 112 |
| Sepsis (%) | 53 (47.3) |
| Intracerebral hemorrhage (%) | 59 (52.7) |
| Age (mean (SD)) | 63.74 (16.66) |
| Sex = male (%) | 65 (58.6) |
| Race (%) | |
| Asian | 4 (3.6) |
| Black | 35 (31.2) |
| White | 73 (65.2) |
| Ethnicity (%) | |
| Hispanic or Latino | 13 (11.7) |
| Not Hispanic or Latino | 97 (87.4) |
| Unknown or Not Reported | 1 (0.9) |
| Pre-existing dementia | 7 (6.3) |
| Baseline disability by modified Ranking Scale (median [IQR]) | 0 [0, 2] |
| Glasgow Coma Scale at initial presentation (median [IQR]) | 13.00 [10.00, 15.00] |
| ICH Score (median [IQR], only reported for patients with ICH) | 1.00 [1.00, 2.00] |
| Sepsis patients in shock at initial presentation (%) | 46 (88.5) |
| Exposures During Circadian Characterization Interval | |
| Median Glasgow Coma Scale score over 24 hours (median [IQR]) | 14.00 [10.00, 15.00] |
| Glasgow Coma Scale score nadir (median [IQR]) | 14.00 [8.00, 15.00] |
| Median Richmond Agitation Sedation Scale score over 24 hours (median [IQR]) | 0.00 [−2.00, 0.00] |
| Richmond Agitation Sedation Scale score nadir (median [IQR]) | −1.00 [−3.25, 0.00] |
| Delirium by CAM-ICU (%) | 10 (8.9) |
| Sequential Organ Failure Assessment score (SOFA; median [IQR]) | 5 [2.75, 9] |
| SOFA for sepsis patients only | 7 [3, 11] |
| Mechanical ventilation (%) | 43 (38.4) |
| Intravenous sedatives (%) | 46 (41.1) |
| SOFA blood pressure categories (%) | |
| 0: No hypotension | 57 (50.9) |
| 1: MAP <70 mmHg | 20 (17.9) |
| 3: Dopamine >5, epinephrine ≤0.1, or norepinephrine ≤0.1 mcg/kg/min | 12 (10.7) |
| 4: Dopamine >15, epinephrine >0.1, or norepinephrine >0.1 mcg/kg/min | 23 (20.5) |
| Acute kidney injury by KDIGO category (%) | |
| No AKI | 79 (71.2) |
| Stage 1 | 15 (13.5) |
| Stage 2 | 11 (9.9) |
| Stage 3 | 6 (5.4) |
| Renal replacement therapy (%) | 2 (1.8) |