Coadministration of naldemedine with a P-gp inhibitor (cyclosporine) or CYP3A inhibitors (itraconazole or fluconazole) increased naldemedine exposure

Coadministration of naldemedine with a CYP3A inducer (rifampin) decreased naldemedine exposure

Single doses of naldemedine were generally safe and well tolerated in healthy subjects when naldemedine was administered alone or in combination with cyclosporine, itraconazole, fluconazole, or rifampin