Table 2.
Indirect treatment comparison and meta-analysis outcomes—1-year mean change from baseline in IOP
| Strategy | IOP change (mmHg) | No. RCTs | I2 | ||
|---|---|---|---|---|---|
| Mean | 95% CI low | 95% CI upper | |||
| Cataract surgery alone | − 2.05 | − 3.38 | − 0.72 | 4 | 81% |
| One TMBS with cataract surgery | − 3.15 | − 5.66 | − 0.64 | 2 | 39% |
| Two TMBSs with cataract surgery | − 4.85 | − 7.71 | − 1.99 | 1 | NA |
| IS + cataract surgery | − 2.25 | − 4.87 | 0.37 | 1 | NA |
| Exploratory comparisons using meta-analysis effects | |||||
| One or two TMBSs with cataract surgery | − 3.87 | − 6.66 | − 1.08 | 3 | 97% |
| MIGS with cataract surgery | − 3.49 | − 5.52 | − 1.46 | 4 | 97% |
TMBS trabecular micro-bypass stent; IS intracanalicular scaffold; MIGS minimally invasive glaucoma surgeries; mmHg millimeter of mercury; I2 statistic describing the presence of heterogeneity between studies when a meta-analysis was performed; NA not applicable