Table 1.
Hemodynamic variables in part 1
| Baseline | Pretreatment | Reperfusion | ||
|---|---|---|---|---|
| 30 | 60 | |||
| Heart rate (bpm) | ||||
| Con | 341 ± 51 | 333 ± 50 | 281 ± 54 | 255 ± 75 |
| Ram | 311 ± 32 | 304 ± 28 | 257 ± 44 | 251 ± 33 |
| 4P-PDOT+Ram | 296 ± 39 | 276 ± 10 | 213 ± 55 | 247 ± 32 |
| 4P-PDOT | 301 ± 32 | 270 ± 22 | 211 ± 71 | 220 ± 44 |
| Phasic LVP (mmHg) | ||||
| Con | 134 ± 7 | 146 ± 6 | 24 ± 13* | 30 ± 11* |
| Ram | 130 ± 19 | 136 ± 18 | 18 ± 12* | 29 ± 15* |
| 4P-PDOT+Ram | 146 ± 23 | 153 ± 24 | 23 ± 10* | 30 ± 10* |
| 4P-PDOT | 134 ± 21 | 148 ± 19 | 35 ± 18* | 40 ± 11* |
| Coronary flow (ml/min) | ||||
| Con | 15 ± 3 | 15 ± 4 | 8 ± 2* | 7 ± 2* |
| Ram | 15 ± 2 | 15 ± 2 | 7 ± 1* | 6 ± 1* |
| 4P-PDOT+Ram | 15 ± 3 | 13 ± 3 | 6 ± 1* | 5 ± 1* |
| 4P-PDOT | 14 ± 3 | 14 ± 3 | 7 ± 2* | 6 ± 2* |
Con, control; Ram, ramelteon; 4P-PDOT, 4-phenyl-2-propionamidotetralin; LVP, left ventricular pressure
*P < 0.05 vs. baseline
#P < 0.05 vs. Con