Table 2.
Hemodynamic variables in part 2
| Baseline | Pretreatment | Reperfusion | ||
|---|---|---|---|---|
| 30 | 60 | |||
| Heart rate (bpm) | ||||
| Con | 291 ± 27 | 278 ± 18 | 205 ± 56 | 181 ± 55* |
| Ram | 287 ± 30 | 266 ± 32 | 239 ± 46 | 215 ± 45 |
| MPG+Ram | 299 ± 32 | 301 ± 59 | 229 ± 74 | 236 ± 34 |
| MPG+Ram+CsAe | 296 ± 26 | 278 ± 24 | 227 ± 57 | 216 ± 34 |
| MPG+Ram+CsAl | 273 ± 20 | 248 ± 26 | 224 ± 53 | 181 ± 25 |
| Phasic LVP (mmHg) | ||||
| Con | 112 ± 24 | 108 ± 30 | 15 ± 8* | 28 ± 9* |
| Ram | 119 ± 33 | 113 ± 38 | 13 ± 4* | 19 ± 5* |
| MPG+Ram | 139 ± 18# | 137 ± 14# | 10 ± 5* | 17 ± 7* |
| MPG+Ram+CsAe | 120 ± 18 | 121 ± 26 | 17 ± 8* | 20 ± 12* |
| MPG+Ram+CsAl | 143 ± 13# | 137 ± 8# | 20 ± 19* | 27 ± 14* |
| Coronary flow (ml/min) | ||||
| Con | 13 ± 2 | 12 ± 2 | 6 ± 2* | 5 ± 2* |
| Ram | 14 ± 2 | 13 ± 3 | 6 ± 2* | 5 ± 2* |
| MPG+Ram | 16 ± 3 | 18 ± 2# | 7 ± 2* | 6 ± 2* |
| MPG+Ram+CsAe | 15 ± 2 | 15 ± 3 | 6 ± 1* | 5 ± 1* |
| MPG+Ram+CsAl | 13 ± 2 | 14 ± 2 | 5 ± 1* | 4 ± 1* |
Con, control; Ram, ramelteon; MPG, N-2-mercaptopropionylglycine; CsA, cyclosporine A; CsAe, CsA early application; CsAl, CsA late application; LVP, left ventricular pressure
*P < 0.05 vs. baseline
#P < 0.05 vs. Con