Table 4.
Diagnostic criteria of ROC curve for tested parameters and CA 125 and SCC-Ag in total group of CC
| Tested parameters | AUC | SE | 95% C.I. (AUC) | p (AUC = 0.5) |
|---|---|---|---|---|
| ROC criteria in cervical cancer (total) | ||||
| M-CSF | 0.8051 | 0.0383 | 0.730–0.880 | <0.001 |
| MMP-2 | 0.5882 | 0.0566 | 0.477–0.699 | 0.1195 |
| TIMP-2 | 0.6186 | 0.0532 | 0.514–0.723 | 0.0257 |
| CA 125 | 0.7340 | 0.0461 | 0.644–0.824 | <0.001 |
| SCC-Ag | 0.7866 | 0.0383 | 0.711–0.862 | <0.001 |
| M-CSF + CA 125 | 0.8006 | 0.0376 | 0.727–0.874 | <0.001 |
| MMP-2 + CA 125 | 0.5963 | 0.0563 | 0.486–0.707 | 0.0874 |
| TIMP-2 + CA 125 | 0.6166 | 0.0537 | 0.511–0.722 | 0.0299 |
| M-SCF + SCC-Ag | 0.8760 | 0.0296 | 0.818–0.934 | <0.001 |
| MMP-2 + SCC-Ag | 0.7880 | 0.0381 | 0.713–0.863 | <0.001 |
| TIMP-2 + SCC-Ag | 0.8081 | 0.0370 | 0.736–0.881 | <0.001 |
p - statistically significantly larger AUCs compared to AUC = 0.5
Abbreviations: ROC, receiver-operating characteristics; CA, cancer antigen; AUC, area under the ROC curve; SE, standard error; CI, confidence interval; M-CSF, macrophage-colony stimulating
factor; MMP-2, matrix metalloproteinase-2; TIMP-2, tissue inhibitor of metalloproteinase-2