Table 5.
Diagnostic criteria of ROC curve for tested parameters and CA 125 and SCC-Ag in all stages of CC
| Tested parameters | AUC | SE | 95% C.I. (AUC) | p (AUC = 0.5) |
|---|---|---|---|---|
| ROC criteria in cervical cancer (I stage) | ||||
| M-CSF | 0.7109 | 0.0631 | 0.582–0.829 | 0.0011 |
| MMP-2 | 0.5484 | 0.0658 | 0.421–0.678 | 0.4223 |
| TIMP-2 | 0.6747 | 0.0622 | 0.562–0.799 | 0.0064 |
| CA 125 | 0.6429 | 0.0614 | 0.522–0.760 | 0.0188 |
| SCC-Ag | 0.8022 | 0.0521 | 0.709–0.908 | <0.001 |
| M-CSF + CA 125 | 0.8001 | 0.0641 | 0.591–0.839 | <0.001 |
| MMP-2 + CA 125 | 0.5499 | 0.0649 | 0.423–0.677 | 0.4646 |
| TIMP-2 + CA 125 | 0.6661 | 0.0627 | 0.551–0.796 | 0.0088 |
| M-SCF + SCC-Ag | 0.8498 | 0.0440 | 0.768–0.935 | <0.001 |
| MMP-2 + SCC-Ag | 0.7824 | 0.0534 | 0.684–0.891 | <0.001 |
| TIMP-2 + SCC-Ag | 0.8320 | 0.0461 | 0.758–0.932 | <0.001 |
| ROC criteria in cervical cancer (II stage) | ||||
| M-CSF | 0.8042 | 0.0532 | 0.698–0.912 | <0.001 |
| MMP-2 | 0.5564 | 0.0639 | 0.433–0.679 | 0.3915 |
| TIMP-2 | 0.6898 | 0.0611 | 0.558–0.799 | 0.0062 |
| CA 125 | 0.7297 | 0.0571 | 0.604–0.836 | <0.001 |
| SCC-Ag | 0.7973 | 0.0523 | 0.691–0.908 | <0.001 |
| M-CSF + CA 125 | 0.8002 | 0.0559 | 0.678–0.910 | <0.001 |
| MMP-2 + CA 125 | 0.5647 | 0.0634 | 0.441–0.688 | 0.3082 |
| TIMP-2 + CA 125 | 0.6662 | 0.0612 | 0.551–0.782 | 0.0054 |
| M-SCF + SCC-Ag | 0.8857 | 0.0410 | 0.809–0.968 | <0.001 |
| MMP-2 + SCC-Ag | 0.7931 | 0.0529 | 0.698–0.901 | <0.001 |
| TIMP-2 + SCC-Ag | 0.8891 | 0.0458 | 0.748–0.930 | <0.001 |
| ROC criteria in cervical cancer (III and IV stages) | ||||
| M-CSF | 0.8797 | 0.0428 | 0.796–0.951 | <0.001 |
| MMP-2 | 0.6588 | 0.0601 | 0.538–0.776 | 0.0098 |
| TIMP-2 | 0.5107 | 0.0668 | 0.388–0.639 | 0.8124 |
| CA 125 | 0.8114 | 0.0498 | 0.717–0.901 | <0.001 |
| SCC-Ag | 0.7616 | 0.0564 | 0.652–0.879 | <0.001 |
| M-CSF + CA 125 | 0.8702 | 0.0443 | 0.781–0.952 | <0.001 |
| MMP-2 + CA 125 | 0.6698 | 0.0592 | 0.550–0.781 | 0.0039 |
| TIMP-2 + CA 125 | 0.5201 | 0.0649 | 0.398–0.649 | 0.7505 |
| M-SCF + SCC-Ag | 0.8885 | 0.0386 | 0.818–0.962 | <0.001 |
| MMP-2 + SCC-Ag | 0.7881 | 0.0515 | 0.687–0.891 | <0.001 |
| TIMP-2 + SCC-Ag | 0.7607 | 0.0543 | 0.660–0.869 | <0.001 |
p - statistically significantly larger AUCs compared to AUC = 0.5
Abbreviations: ROC, receiver-operating characteristics; CA, cancer antigen; AUC, area under the ROC curve; SE, standard error; CI, confidence interval; M-CSF, macrophage-colony stimulating
factor; MMP-2, matrix metalloproteinase-2; TIMP-2, tissue inhibitor of metalloproteinase-2