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. 2020 May 21;11(5):387. doi: 10.1038/s41419-020-2591-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — The levels of SAV1 and YAP proteins in the tumors from xenograft mice were detected by IHC and IF, respectively. Lycorine raised SAV1 levels (IHC: a, b, ×200; IF: c, ×1000), while YAP amounts were decreased by lycorine treatment (IHC: d, e). The amounts of SAV1, YAP, and β-actin in the tumor tissues from xenograft mice were detected by western blotting (f–h) and RT-PCR (i), respectively. LH + represents with lycorine treatment, LH− represents vehicle control. Data represent the mean ± SD of triplicates. *P < 0.05. **P < 0.01. ***P < 0.001.