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. 2020 May 21;11(5):387. doi: 10.1038/s41419-020-2591-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Lycorine significantly inhibited lung cancer A549 cell migration in a concentration-dependent manner in the wound-healing assay (a, b). Lycorine at a concentration of 2.5 μM markedly reduced the migration of SPC-A-1 (c, e) and A549 (d, e) cells invasion in a transwell analysis. Western blotting showed that YAP siRNA decreased YAP expression and combination of YAP siRNA with lycorine further reduced YAP expression in SPC-A-1 (f, g) and A549 cells ((h, i); meanwhile, YAP siRNA markedly diminished SPC-A-1 cell migration and combination of YAP siRNA with lycorine near completely suppressed further lung cancer cell migration (j, k). Data are shown as mean ± SD of three independent replicates.