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. 2020 May 21;10:8418. doi: 10.1038/s41598-020-65423-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Increase of SIRT3 counteracts podocyte damage and loss in BTBR ob/ob mice. (a,b) Representative images and quantification of glomerular nephrin (a) and nestin (b) expressions (red) in BTBR WT mice (n = 9) and in BTBR ob/ob mice treated with vehicle (n = 6) or honokiol (n = 9) at 14 weeks of age. (c) Representative images and morphometric analysis of glomerular volume, WT1-positive podocytes, expressed as number per glomerulus, and podocyte density in BTBR WT mice (n = 9) and in BTBR ob/ob mice treated with vehicle (n = 6) and honokiol (n = 9) at 14 weeks of age. Scale bars: 20 μm. Data are mean ± SEM and were analyzed by one-way ANOVA followed by Tukey’s multiple comparisons test, ***p < 0.001 vs BTBR WT mice; ^#p < 0.05, ^###p < 0.001 vs BTBR ob/ob + vehicle.