Table 2.

Receiving Operating Characteristic Curve (ROC) Analysis of Serum Biomarkers in the Diagnosis of Fracture-Related Infection

	P/V Ratio	ESR (mm/hr)	CRP (mg/dL)
Optimal Threshold	23.0	35.0	1.2
Area Under the Curve (AUC)	0.814	0.813	0.752
Specificity (95% CI)	55.6% (38.1-72.1)	91.7% (77.53-98.25)	91.7% (77.53-98.25)
Sensitivity (95% CI)	100.0% (80.5-100)	64.7% (38.3-85.8)	47.1% (22.98-72.19)
Accuracy	69.8%	83.0%	77.4%
Positive Likelihood Ratio	2.3	7.8	5.7
Negative Likelihood Ratio	0.0	0.4	0.6
Positive Predictive Value	51.5%	78.6%	72.7%
Negative Predictive Value	100.0%	84.6%	78.6%
Standard Error	0.0111	0.0674	0.0735
95% Confidence Interval	0.683-0.907	0.682-0.907	0.615-0.861
Z-Statistic	5.420	4.645	3.433
Significance	<0.001	<0.001	0.006

*P/V = Platelet Count to Mean Platelet Volume Ratio; ESR = Erythrocyte Sedimentation Rate; CRP = C-Reactive Protein; CI = Confidence Interval.