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. 2020 May 21;10:8429. doi: 10.1038/s41598-020-65300-w

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effects of OBX, ketamine (Ket), guanosine (GUO) and pre-treatment with rapamycin (RAP) on the splash test (SPT). (a) experimental design; (b) compares naïve, Sham and OBX groups; (c) effects of Ket and GUO in Sham and OBX mice; (d) effects of RAP pre-treatment on Sham and OBX mice treated with Ket or GUO. One-way ANOVA/Tukey´s was used to compare the Naïve, Sham and OBX groups (n = 8–20). The effects of treatment (Ket or GUO, n = 15–20) were compared by Two-way ANOVA/Tukey. The effects of RAP pre-treatment (n = 12–20) were compared by Three-way ANOVA/Tukey. Columns represent mean ± S.E.M. *p < 0.05 compared to the respective Sham group; ^ap < 0.05, and ^aaap < 0.001 compared to KET and GUO groups (respectively) without Rap pre-treatment.