Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 May 21;10:8429. doi: 10.1038/s41598-020-65300-w

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Effects of ketamine (Ket) and guanosine (GUO), and pretreatment with rapamycin (RAP), on the open field (OFT) and novel object recognition test (NORT) in Sham and OBX mice. OFT and NORT were performed 48 h after treatments. (a) experimental design; OFT was conducted 90 min before NORT training, and test performed 90 min post training. Left column: OFT: distance travelled by naïve, Sham and OBX groups (b), effects of Ket and GUO (c), effects of RAP pretreatment (d). Middle column: NORT training: naïve, Sham and OBX groups (e), effects of Ket or GUO (f), effects of RAP pre-treatment (g) groups. Left column: NORT test: naïve, Sham and OBX groups (h), effects of Ket or GUO (i), effects of RAP pre-treatment (j). Inserts represent locomotor activity. One-way ANOVA/Tukey´s was used to compare the Naïve, Sham and OBX groups (n = 8–20). FO = familiar object; NO = novel object Distance travelled by Sham or OBX groups in OFT and NORT were analyzed by two-way ANOVA/Tukey. Data with RAP pre-treatment were analyzed by three-way ANOVA/Tukey for distance travelled and three-way ANOVA/Sidak for NORT, n = 12–20. Columns represent mean ± S.E.M. * p < 0.05, * p < 0.01 and ***p < 0.001 compared to the respective Sham group.