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. 2020 May 21;11(5):383. doi: 10.1038/s41419-020-2598-6

Fig. 1. NLRP3 inflammasome activation and MARK4 increase in diabetic patients and rats.

Fig. 1

a Plasma interleukin (IL)-1β and IL-18 were measured in diabetic patients and heathy controls (con: n = 30, DM: n = 50). bg The mRNA expression of IL-1β, IL-18, NLRP3, caspase 1, ASC and MARK4 was examined by qPCR in PBMCs from subjects (con: n = 30, DM: n = 50). h Results from western blot analysis of NLRP3, caspase 1, ASC and MARK4 expression in PBMCs from subjects (con: n = 30, DM: n = 50). i Plasma IL-1β and IL-18 were measured in the control group and diabetic group in rats (n = 5/group). jl The mRNA expression of IL-1β, IL-18, NLRP3, caspase 1, ASC and MARK4 was examined by qPCR in aorta tissues from the control group and diabetic group in rats (n = 5/group). m Results from western blot analysis of NLRP3, caspase 1, ASC and MARK4 expression in aorta tissues from the control group and diabetic group in rats (n = 5/group). n Immunostaining of MARK4 in aorta tissues from the control group and diabetic group (n = 5/group). Scale bar, 20 μm. (*P ≤ 0.001, **P ≤ 0.0001, compared with the control group).