Table 2.
The comparisons of cerebrospinal fluid neuroplasticity-associated protein levels between each psychiatric group and control group.
| Schizophrenia (n = 94) | Bipolar disorder (n = 68) | Major depressive disorder (n = 104) | Control (n = 118) | |||||
|---|---|---|---|---|---|---|---|---|
| Mean ± standard deviation | vs. control | Mean ± standard deviation | vs. control | Mean ± standard deviation | vs. control | Mean ± standard deviation | Statistical comparison | |
| APP (ng/ml) | 498.5 ± 206.5 | p = 0.019 (0.11) | 475.9 ± 221.1 | p = 0.002 (0.011) | 537.3 ± 256.7 | p = 0.12 | 584.3 ± 266.0 | F(3, 378) = 3.78, p = 0.011, partial η2 = 0.029 |
| Contactin-1 (pg/ml) | 4272.5 ± 486.1 | p = 0.089 | 4270.9 ± 586.9 | p = 0.060 | 4367.2 ± 569.4 | p = 0.45 | 4419.1 ± 581.9 | F(3, 378) = 1.60, p = 0.19, partial η2 = 0.013 |
| ErbB3 (pg/ml) | 2539.1 ± 648.4 | p = 0.43 | 2545.0 ± 908.6 | p = 0.10 | 2649.2 ± 764.9 | p = 0.50 | 2682.9 ± 951.8 | F(3, 378) = 0.89, p = 0.45, partial η2 = 0.007 |
| GDNF (pg/ml) | 6.3 ± 1.2 | p = 0.035 (0.21) | 6.5 ± 1.5 | p = 0.27 | 6.7 ± 1.3 | p = 0.63 | 6.7 ± 1.3 | F(3, 378) = 1.65, p = 0.18, partial η2 = 0.013 |
| HGF (pg/ml) | 81.4 ± 18.5 | p = 0.38 | 86.8 ± 21.1 | p = 0.66 | 86.1 ± 20.7 | p = 0.78 | 84.8 ± 21.2 | F(3, 378) = 0.61, p = 0.61, partial η2 = 0.005 |
| HGF receptor (pg/ml) | 1105.8 ± 473.5 | p = 0.33 | 1030.8 ± 547.3 | p = 0.060 | 1197.5 ± 567.5 | p = 0.86 | 1187.6 ± 590.8 | F(3, 378) = 1.69, p = 0.17, partial η2 = 0.013 |
| NCAM-1 (ng/ml) | 172.4 ± 50.0 | p = 0.25 | 165.0 ± 59.9 | p = 0.017 (0.097) | 178.4 ± 59.0 | p = 0.39 | 184.0 ± 63.5 | F(3, 378) = 1.95, p = 0.12, partial η2 = 0.015 |
| Neuropilin-1 (pg/ml) | 3075.4 ± 857.0 | p = 0.57 | 2981.4 ± 1238.4 | p = 0.15 | 3189.6 ± 1182.0 | p = 0.96 | 3199.5 ± 1104.1 | F(3, 378) = 0.82, p = 0.48, partial η2 = 0.006 |
| S100B (pg/ml) | 818.3 ± 227.8 | p = 0.72 | 830.3 ± 287.4 | p = 0.98 | 819.6 ± 324.4 | p = 0.81 | 831.4 ± 290.1 | F(3, 378) = 0.60, p = 0.98, partial η2 = 0.000 |
| VEGF receptor 1 (pg/ml) | 37.2 ± 12.7 | p = 0.12 | 33.3 ± 15.2 | p = 0.51 | 33.2 ± 15.0 | p = 0.42 | 34.5 ± 15.1 | F(3, 378) = 2.08, p = 0.10, partial η2 = 0.016 |
| VEGF receptor 2 (pg/ml) | 664.7 ± 212.7 | p = 0.90 | 683.4 ± 287.3 | p = 0.67 | 674.2 ± 268.8 | p = 0.78 | 668.1 ± 223.2 | F(3, 378) = 0.07, p = 0.98, partial η2 = 0.001 |
APP amyloid precursor protein, GDNF glial cell line-derived neurotrophic factor, HGF hepatocyte growth factor, NCAM neural cell adhesion molecule, S100B S100 calcium-binding protein B, VEGF vascular endothelial growth factor.
Significant p values are shown in bold cases (right parentheses indicate corrected p values).