Skip to main content
. 2020 May 21;11(5):388. doi: 10.1038/s41419-020-2605-y

Fig. 5. Mutant CaMKIIδC T287A inhibited calpain activity, reduced α-fodrin degradation, and improved membrane integrity.

Fig. 5

a Grouped results of calpain activity. Values are expressed as a percentage of the control in the sham group. b Representative blots of full length and 150 kDa fragments of α-fodrin, as well as grouped results of the densitometric analysis. GAPDH was used as a loading control and the ratio of the fragments to total signal per lane is expressed as a percentage of the control in the sham group. c Representative confocal images for Evans blue uptake. Scale bar, 25 μm. Each bar represents the mean ± SEM, n = 8 rats in each group. Western blots were performed in five independent biological experiments and for three technical replicates per sample. *P < 0.05, ##, **P < 0.01. I/R ischemia/reperfusion, AAV-V AAV vector, CaMKII-M AAV expressing mutant CaMKIIδC T287A.