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. 2020 May 21;10:8425. doi: 10.1038/s41598-020-65339-9

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Switching of Sox9 expression during the formation of the musculoskeletal system. Sagittal plane images of the TMJ at (a) E13 and (c) E16. (b, d) Graph of the measured Sox9⁺ progenitor cell luminance. (e) High-magnification view of the MTJ in (a) and (f) high-magnification view of the MTJ in (c). (g) Occupancy rate of Sox9 expression. The fluorescence intensity vs. distance plot shows that Sox9 expression was identified in (a, b) future tendons, bone, and MTJ regions at E13.5 and in (c, d) cartilage cells at E16. The comparison of fluorescence intensity indicated that the intensity was>50 in the region of the MTJ at E13 but was <100 in the region of the MTJ at E16 (b, d). (e–g) The occupancy rate of Sox9 expression in the MTJ at E13 was high compared to that in the MTJ at E16 (*P < 0.05). Sox9, SRY-box containing gene 9; B, bone; M, muscle; T, tendon; MTJ, myotendinous junction.