Fig. 1.

Changes in dry eye signs following Lacrimera treatment. Prolonged treatment with Lacrimera a increased tear film stability, b promoted tear accumulation, and c restored the corneal surface at 1 month in comparison to baseline. The number of patients with intact corneas (“none”) increases following treatment with Lacrimera eye drops. Values are presented as mean ± standard deviation. In case both eyes were affected, only the score with the highest severity was considered. n ≥ 18 patients for all clinical parameters at baseline and at 1 month. Statistical significance of the change from baseline was assessed by paired two-tailed Student’s t test. TBUT is a measure of tear film stability, with shorter times indicating a greater abnormality. Schirmer’s test evaluates tear secretion, with shorter lengths indicating a greater abnormality. The corneal surface was assessed by fluorescein staining