Table 3.
Management and outcomes of patients
| RCT |
Observational studies |
|||||||
|---|---|---|---|---|---|---|---|---|
| No. of studies (No. of patients) | Weighted mean, % (95% CI) |
P values RCT vs observational studies |
No. of studies comparing T1MI and T2MI (No. of patients) | T1MI weighted mean, % (95% CI) | T2MI observational studies % weighted mean, (95% CI) |
P values T1MI vs T2MI | ORs of T2MI compared with T1MI (95% CI) | |
| In-hospital initiation of DAPT | NA | NA | NA | 6 (19,480) | 74.2 (66.0-81.0) | 20.8 (4.1-34.2) | < 0.0001 | 0.09 (0.04-0.21) |
| Coronary angiography | 35 (83,466) | 99.8 (99.7-99.9) | < 0.0001 | 8 (35,795) | 82.9 (77.8-87.0) | 28.2 (18.5-40.4) | < 0.0001 | 0.28 (0.20-0.39) |
| PCI | 34 (78,358) | 99.8 (99.6-99.9) | < 0.0001 | 9 (36,825) | 64.4 (52.8-74.6) | 10.3 (4.3-22.6) | < 0.0001 | 0.17 (9.1-32.7) |
| Reinfarction | 4 (5,321) | 3.3 (2.6-4.2) | < 0.0001 | 5 (5396) | 9.8 (6.3-14.9) | 6.4 (4.0-10.1) | 0.002 | 0.62 (0.47-0.84)∗ |
| Short-term mortality | 12 (97,269) | 2.9 (1.7-4.9) | < 0.0001 | 8 (7249) | 7.1 (5.5-8.8) | 15.6 (10.3-20.8) | 0.0006 | 1.86 (1.20-2.88)∗ |
| Long-term mortality | 4 (33,593) | 3.6 (2.3-5.4) | < 0.0001 | 16 (46,947) | 11.3 (6.4-19.2) | 27.7 (20.6-36.1) | < 0.0001 | 2.47 (2.06-2.96)∗ |
| 11 (42,912) |
1.45 (1.25-1.69)† | |||||||
CI, confidence interval; DAPT, dual antiplatelet therapy; NA, nonapplicable (due to randomized comparison of dual antiplatelet therapy vs placebo); PCI, percutaneous coronary intervention; RCT, randomized controlled trials; T1MI, type 1 myocardial infarction; T2MI, type 2 myocardial infarction.
∗
Unadjusted comparison.
†
Adjusted comparison.