FIGURE 2.

Comparison of (A) IgG₁-, (B) IgG₂- and (C) IgG₃-specific glycosylation profiles between healthy controls and EOC patients. Relative abundance of given glycosylation traits was obtained by summing up relative intensities of the corresponding tryptic glycopeptides detected by MALDI-TOF-MS. Bars represent mean relative abundance and error bars represent standard deviation. p-values were obtained from regression analysis, adjusting for age and patients’ status (0 = healthy control, 1 = EOC). After Bonferroni correction for glycosylation traits, statistically significant differences are indicated as ^∗p ≤ 0.008, ^∗∗p ≤ 0.001 and ^∗∗∗p ≤ 0.0001 in case of IgG₁ and IgG₃, and ^∗p ≤ 0.01, ^∗∗p ≤ 0.002 and ^∗∗∗p ≤ 0.0002 in case of IgG₂.