TABLE 3.

Associations between IgG glycosylation traits, EOC and age.

Glycosylation trait		IgG1			IgG2			IgG3
		β	95% CI	p	β	95% CI	p	β	95% CI	p
Agal	(1) EOC	11.285	7.831, 14.738	1.3E−9	6.056	2.737, 9.374	4.2E−4	9.120	5.242, 12.998	7.6E−6
	(2) Age	0.418	0.256, 0.580	9.9E−7	0.524	0.369, 0.680	4.4E−10	0.609	0.428, 0.789	5.7E−10
Monogal	(1) EOC	−5.690	−7.630, −3.750	3.6E−8	−3.591	−5.666, −1.516	8.0E−4	−3.516	−5.369, −1.663	2.6E−4
	(2) Age	−0.118	−0.209, −0.027	0.011	−0.260	−0.357, −0.163	4.2E−7	−0.162	−0.249, −0.076	3.0E−4
Digal	(1) EOC	−5.596	−7.466, −3.726	2.0E−8	−2.465	−3.927, −1.003	1.1E−3	−5.604	−8.216, −2.992	4.0E−5
	(2) Age	−0.299	−0.387, −0.212	2.8E−10	−0.264	−0.333, −0.196	2.3E−12	−0.446	−0.568, −0.325	2.5E−11
Sial	(1) EOC	−0.576	−0.949, −0.202	0.003	−0.052	−0.644, 0.539	0.861	−2.360	−4.229, −0.492	0.014
	(2) Age	−0.039	−0.057, −0.022	1.9E−5	−0.072	−0.100, −0.044	8.3E−7	−0.275	−0.362, −0.188	4.6E−9
Bisec	(1) EOC	−0.852	−2.141, 0.437	0.193	−0.774	−1.764, 0.215	0.124	−0.564	−1.517, 0.388	0.244
	(2) Age	0.052	−0.008, 0.112	0.091	0.038	−0.009, 0.084	0.110	0.084	0.040, 0.128	2.7E−4
Fuc	(1) EOC	1.025	0.403, 1.648	0.001	–	–	–	0.459	−1.081, 1.998	0.557
	(2) Age	0.005	−0.024, 0.034	0.721	–	–	–	0.096	0.024, 0.168	0.009

For all glycosylation traits, regression beta coefficients (β) are reported together with their 95% confidence interval (95% CI) and respective p-values (p). Bonferroni corrected p-values smaller than or equal to 0.008 (for IgG₁ and IgG₃; 0.05/6 glycosylation traits) and 0.01 (for IgG₂; 0.05/5 glycosylation traits) were considered as statistically significant and are highlighted in bold. Representations of glycosylation traits are given in terms of Agal (agalactosylation), Monogal (monogalactosylation), Digal (digalactosylation), Sial (sialylation), Bisec (bisecting GlcNAc) and Fuc (core-fucosylation).