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. 2020 Mar 18;12(2):519–539. doi: 10.1007/s12551-020-00680-x

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© The Author(s) 2020

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Fig. 2 — Model of chaperone function of NIRs for RBPs in cells. NIRs (pink) actively carry nascently translated proteins (green lines) or proteins in physiological SGs (green circles) into the nucleus, preventing LLPS from occurring in the cytoplasm. Small GTPase Ran (blue) displaces the proteins and binds NIR in the nucleus. In the absence of this regulatory system, physiological SGs could then subsequently transform into aberrant SGs (yellow) and irreversible aggregates (red) in the cytoplasm