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. 2020 May 15;11:696. doi: 10.3389/fphar.2020.00696

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Copyright © 2020 Wang, Bai, Zhang, Ge, Wang, Liang, Li, Gu, Li, Xu, Yang, Xu, Geng and Zhou

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PUN inhibited ovariectomized induced bone loss and reduced osteoclast number. (A) H&E staining, (B) TRAP staining, (C) Quantitative analyses of histomorphometric bone parameters of BV/TV (%), (D) Quantitative analyses of histomorphometric bone parameters of BS (mm²), (E) Quantitative analyses of number of TRAP-positive osteoclasts/bone surface (N.Oc/BS, 1/mm). *p < 0.05, **p < 0.01 compared with the OVX group, n = 5 per group. Scale bar, 100 μm, 25 μm.