Table 2.
Reductions in Dlco and FEV1 Are Associated With Increased COPD Morbidity
| Outcome | Dlco % Predicted |
FEV1 % Predicted |
||
|---|---|---|---|---|
| Regression Coefficient (95% CI) | P Value | Regression Coefficient (95% CI) | P Value | |
| CAT score | 0.53 (0.33 to 0.73) | < .001 | 1.16 (0.96 to 1.36) | < .001 |
| SGRQ score | 1.67 (1.23 to 2.1) | < .001 | 2.94 (2.58 to 3.31) | < .001 |
| Activity | 2.58 (1.74 to 3.41) | < .001 | 3.99 (3.48 to 4.51) | < .001 |
| Impact | 1.3 (0.86 to 1.74) | < .001 | 2.25 (1.86 to 2.64) | < .001 |
| Symptom | 1.23 (0.70 to 1.76) | < .001 | 3.33 (2.93 to 3.72) | < .001 |
| SF-36 Physical Function | –0.89 (–1.18 to –0.6) | < .001 | –1.29 (–1.58 to –1.00) | < .001 |
| SF-36 Mental | 0.03 (–0.37 to 0.42) | .900 | –0.01 (–0.31 to 0.31) | .954 |
| 6MWD, feet | –45.35 (–58.21 to –32.48) | < .001 | –43.26 (–48.36 to –38.15) | < .001 |
| Resting Spo2, % | –0.22 (–0.38 to –0.05) | .012 | –0.19 (–0.24 to –0.14) | < .001 |
Associations are per 10% decrease in percent predicted Dlco or percent predicted FEV1. Models (N = 1,564) include age, sex, BMI category, ethnicity, education, smoking pack-years, smoking status, anemia status, diabetes status, congestive heart failure status, sleep apnea status, %LAA-950 (emphysema), percent predicted FEV1, and percent predicted Dlco. See Table 1 legend for expansion of abbreviations.