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Enrichment of De Novo LGD Variants in Very Early Onset (≤ 5 Years of Age) Compared With Older (> 5-18 Years of Age) Pediatric Patients
| Variant Type | Age ≤ 5 y (n = 16) | Age > 5-18 y (n = 18) | Enrichment | P Value |
|---|---|---|---|---|
| SYN | 2 | 8 | 3.6 | .12 |
| Mis | 10 | 16 | 1.4 | .44 |
| D-Mis | 3 | 6 | 1.8 | .51 |
| LGD | 6 | 0 | NA | .01 |
Bold font indicates statistically significant data. NA = not applicable. See Table 2 legend for expansion of other abbreviations.
