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Stability of HIF-1α subunit under Normoxia (A) and Hypoxia (B) conditions. Under normoxia (A), prolyl hydroxylase domain enzymes mediate HIF-1α subunit degradation of HIF by hydroxylation-induced proteasome—mediated pathway. In contrast under hypoxia (B), molecular oxygen is not available for hydroxylation that favors HIF-1α stabilization. Stable HIF-1α binds with HIF-1β subunit to bind with core promoter sequence of HIF-1α target genes.
