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. 2020 May 15;7:193. doi: 10.3389/fmed.2020.00193

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Copyright © 2020 Liu, Liao, Zhang, Lin, He, Fang, Tu, Zhao, Wu and Gu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The relationship between significant FC and pain or fatigue as measured by TBP or FSS (p < 0.05, Bonferroni corrected): (A) FC between node 115 (mPFC) and node 208 (INS.L) was positively[[Inline Image]] associated with both pain and fatigue; (B) FC between node 115 (mPFC) and node 262 (ITG.L) was positively associated with fatigue; (C) FC between node 92 (PCC.R) and node 107 (ACC.L) was negatively associated with fatigue. mPFC, medial prefrontal cortex; INS.L, left insula; ITG.L, left inferior temporal cortex; PCC.R, right posterior cingulate cortex; ACC.L, left anterior cingulate cortex.