Table 2.
Nodal topological differences between AS patients and HC.
| Node* | Peak MNI Coordinate | Approximate structure | Network | Direction | p-value (FDR corrected) |
|---|---|---|---|---|---|
| Betweenness centrality | |||||
| 18 | −7,−33, 72 | Paracentral lobule_L | SMN | AS > HC | 0.032 |
| 41 | 38,−17, 45 | Precentral lobule_R | SMN | AS > HC | 0.01 |
| 49 | 19,−8, 64 | Superior frontal gyrus_R | TCN | AS < HC | 0.022 |
| 92 | 8,−48, 31 | Posterior cingulate _R | DMN | AS < HC | 0.009 |
| 109 | −3, 44,−9 | Middle frontal gyrus_R | DMN | AS < HC | 0.015 |
| 115 | −8, 48, 23 | Medial prefrontal cortex | DMN | AS > HC | 0.013 |
| 188 | −42, 38, 21 | Middle frontal gyrus_L | TCN | AS > HC | 0.03 |
| 208 | −35, 20, 0 | Insula_L | SN | AS > HC | 0.046 |
| 211 | 34, 16,−8 | Insula_R | SN | AS > HC | 0.008 |
| 227 | −22, 7,−5 | Putamen_L | Subcortical | AS < HC | 0.011 |
| 230 | 23, 10, 1 | Putamen_R | Subcortical | AS < HC | 0.023 |
| 260 | −27,−71, 37 | Superior occipital gyrus_L | DAN | AS > HC | 0.045 |
| Degree centrality | |||||
| 7 | 17,−28,−17 | Parahippocampal gyrus_R | Uncertain | AS < HC | 0.011 |
| 22 | 10,−46, 73 | Precuneus _R | SMN | AS < HC | 0.025 |
| 49 | 19,−8, 64 | Superior frontal gyrus_R | TCN | AS < HC | 0.037 |
| 107 | −7, 51,−1 | Anterior cingulate_L | DMN | AS < HC | 0.033 |
| 141 | 17,−91,−14 | Lingual gyrus _R | Uncertain | AS > HC | 0.015 |
| 165 | 26,−79,−16 | Cerebelum_R | Visual | AS > HC | 0.031 |
| 172 | −33,−79,−13 | Fusiform gyrus_L | Visual | AS > HC | 0.02 |
| 208 | −35, 20, 0 | Insula_L | SN | AS > HC | 0.005 |
| 260 | −27,−71, 37 | Superior occipital gyrus_L | DAN | AS > HC | 0.043 |
| 263 | −17,−59, 64 | Superior parietal gyrus_L | DAN | AS > HC | 0.015 |
*
Node number based on power 264-ROI atlas. DMN, default mode network; SN, salience/network; DAN, dorsal attention network; SMN, sensory/somatomotor network; TCN, fronto-parietal task control network.