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. 2020 Apr 13;295(20):6785–6797. doi: 10.1074/jbc.RA120.013679

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© 2020 Gordon et al.

Published under exclusive license by The American Society for Biochemistry and Molecular Biology, Inc. This article is made available via the PMC Open Access Subset for unrestricted re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the COVID-19 pandemic or until permissions are revoked in writing. Upon expiration of these permissions, PMC is granted a perpetual license to make this article available via PMC and Europe PMC, consistent with existing copyright protections.

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Figure 4. — Patterns of inhibition of RNA synthesis with RDV-TP. A, RNA primer/template substrates used to test multiple (left) or single (right) incorporations of RDV-TP. G indicates incorporation of the radiolabeled nucleotide opposite template position 5. RDV-TP incorporation is indicated by i. RDV-TP incorporation was monitored with purified CoV RdRp complexes (B) and LASV L protein (C) in the presence of the indicated combinations of NTPs and RDV-TP.