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. 2020 Apr 2;295(20):7113–7125. doi: 10.1074/jbc.RA119.011895

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© 2020 Ray et al.

Author's Choice—Final version open access under the terms of the Creative Commons CC-BY license.

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Figure 3. — Samd14 SAM is evolutionarily conserved. A, sequence of murine Samd14. B, left, sequence alignment of the SAM domain of Samd14 among vertebrate species. Alignment was conducted with Clustal Omega and visualized with JalView. Right, phylogenetic tree, generated by neighbor-joining of aligned sequence (JalView) of Samd14 among organisms that contain the annotated gene. C, sequence alignment of SAM domains. H1–H5 represent helical regions determined by in silico alignment of Samd14 with the solved structure of SHIP2 (37).