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. 2020 May 15;11:938. doi: 10.3389/fimmu.2020.00938

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Copyright © 2020 Grzywa, Sosnowska, Matryba, Rydzynska, Jasinski, Nowis and Golab.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Scheme for arginine metabolism. In mammalian cells, L-Arginine is a substrate for four enzymes: ARG, NOS, ADC, AGAT. L-Arginine downstream metabolites are components of multiple metabolic pathways and are necessary for cells proliferation and collagen synthesis. ADC, arginine decarboxylase; AGAT, arginine:glycine amidinotransferase; AGMase, agmatinase; ARG, arginase; ASL, argininosuccinate lyase; ASS, argininosuccinate synthase; GAMT, guanidinoacetate N-methyltransferase; NOS, nitric oxide synthase; OAT; ornithine aminotransferase; OTC, ornithine transcarbamylase; P5C, pyrroline-5-carboxylic acid. Figure was modified from Servier Medical Art, licensed under a Creative Common Attribution 3.0 Generic License. http://smart.servier.com/.